ea0011p602 | Neuroendocrinology and behaviour | ECE2006
Lewis BM
, Francis K
, Monk P
, Scanlon MF
, Ham J
Complement C5a is associated with various pro-inflammatory effects such as chemotaxis, production of superoxides, histamine release, vasodilatation and smooth muscle contraction. In sepsis, excessive production of C5a can lead to multi-organ failure. C5a mediates its actions through the C5a receptor (C5aR) but may also bind to a second receptor called C5L2 that acts as a decoy for removing excess C5a. C5a is also rapidly cleaved to a less active form, C5adesR; C5L2, in contras...